Applications of the excimer laser: a review. Transmission of the beam of light is achieved by using an articulated arm. Because XTRAC delivers a highly targeted, therapeutic beam of UVB light only to areas of the skin affected by psoriasis, healthy skin surrounding the lesions stays that way. As its usage as a targeted monotherapy increases, future trials should consider evaluating and modifying these parameters to determine the most optimal management of localized psoriasis. Lebwohl M. Psoriasis. J Am Acad Dermatol. 308 nm UVB excimer laser for psoriasis. 2002;1010–1013. 2014;4:197–205. Dr. KothiwalaSkinEva Clinic offers state-of-the-art excimer laser treatment for psoriasis and vitiligopatients. It has a range of efficacies depending on the protocol used with several different treatment protocols, including the induration protocol, the minimal erythema dose protocol, and the newer minimal blistering dose protocol. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2014 Sep 15;7(9):2844-50. eCollection 2014. From editorial acceptance to publication. The 308 nm excimer laser has the ability to treat mild, moderate and even severe but localised psoriasis plaques and plays an important role in the treatment management of psoriasis. This protocol identifies the minimum dose at which the patient will blister, and then subsequent treatments are administered at doses less than the MBD. 2007 Dec;23(6):238-41. doi: 10.1111/j.1600-0781.2007.00317.x. The combined analysis of these studies showed that $64 of patients with palmoplantar pustular psoriasis experienced an improvement of at least 70% at the end of treatment. 2009;361:496–509. XTRAC is the only FDA-cleared, clinically proven excimer laser that gets skin clear of psoriasis—and it works fast, with many patients seeing significant improvement and long-lasting remissions. When compared to the narrow band UVB laser, the 308 nm laser has an increased induction rate of T-cell apoptosis.1 Compared with traditional narrow band UV therapy, the excimer laser requires on average less number of treatment sessions and thus a smaller amount of cumulative UVB exposure. The three main protocols that were identified were the MED protocol, the Induration protocol, and the MBD protocol. An optimal therapeutic dose protocol with excimer laser for the treatment of plaque psoriasis yielded more effective dosing in fewer treatment sessions, … J Am Acad Dermatol. Because the laser light never touches the surrounding skin, it reduces the risk of UV radiation exposure. Methods: Carrascosa JM, Soria X, Domingo H, Ferrandiz C. Treatment of inverse psoriasis with excimer therapy and tacrolimus ointment. J Am Acad Dermatol. Hyperpigmentation was the most common side effect in the pediatric group. 308-nm excimer laser for the treatment of psoriasis: a dose-response study. You can learn about our use of cookies by reading our Privacy Policy. When treating patients with the excimer laser it is important to identify both the optimal patient candidate and the appropriate treatment protocol. We also retain data in relation to our visitors and registered users for internal purposes and for sharing information with our business partners. One study by Asawanonda et al extrapolates dosing in millijoules from a mean MED of 203.3 mJ to correlate with ~3.248 mJ.21,22, The induration-based protocol is another method for determining treatment dosing. Successful use of the excimer laser for generalized psoriasis in an ustekinumab non-responder. Over the years the excimer laser has evolved in its clinical usage, and appropriately, so have the treatment protocols that are used in clinical practice. The study was conducted by Dr. Albert Marchetti, a leading health economic researcher and an adjunct professor at Rutgers New Jersey Medical School, and compared common interventions to treat plaque psoriasis. On average, plaques treated with this protocol achieved PASI-75 after 10 treatments.34, One report published by Debbaneh et al describes using a minimal blister dose (MBD) for excimer laser treatment. Arch Dermatol. This article has no funding source. Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email PDF copies to you promptly. PRACTICAL EXPERIENCE. This demonstrated that the combination of excimer laser with alternating clobetasol spray and calcitriol ointment is a promising option and can easily be implemented in any treatment involving the excimer laser.30, In another 12-week study Levin et al treated moderate to severe psoriasis patients with twice weekly excimer treatments combined with twice daily clobetasol propionate followed by calcitriol ointment twice daily. J Drugs Dermatol. The right-hand nails were treated with excimer laser twice weekly for 12 weeks and the left-hand nails were treated with PDL once every 4 weeks for a total of 12 weeks. These studies also confirm that an average of 10 treatments should clear the plaques.18–22, In addition to plaque psoriasis, the 308 nm laser is useful in the treatment of intertriginous psoriasis as demonstrated by a few case reports.23,24 Recently, split scalp studies have shown beneficial results of the laser in treating scalp psoriasis. J Lasers Med Sci. It means that the treatment will not work well for psoriasis cases that affect large parts of the body. Gordon KB, Ruderman EM. The patient was subsequently treated with high-dose excimer laser therapy and demonstrated a rapid improvement in PASI scoring. Comparison of the efficacy and safety of the 308 nm excimer laser for the treatment of localized psoriasis in adults and in children: a pilot study. 2012;66:664–672.
Effectiveness Usually, two to three treatments with the excimer laser a week for about 10 to 15 weeks will achieve substantial improvement in a plaque of psoriasis. Mudigonda T, Dabade T, Feldman S. A review of targeted ultraviolet B phototherapy for psoriasis. Wong JW, Nguyen TV, Bhutani T, Koo JY. Physica-Verlag, Springer: Heidelberg. The three main protocols that were identified were the MED protocol, the Induration protocol, and the MBD protocol. Trehan M, Taylor CR. Patients who had a history of nonre-sponse to UVB phototherapy, koebnerization, or hand or foot involvement with psoriasis were also excluded. 2002;28:530–532. Open access peer-reviewed scientific and medical journals. J Dermatolog Treat. Seven prospective studies were found describing the excimer efficacy for psoriasis. J Dermatolog Treat. Treatment for palmoplantar pustular psoriasis: systematic literature review, evidence-based recommendations and expert opinion. Supraerythemogenic excimer laser in combination with clobetasol spray and calcitriol ointment for the treatment of generalized plaque psoriasis: interim results of an open label pilot study. In their 12-week study, patients received twice weekly treatment with the 308 nm excimer laser combined with clobetasol propionate twice daily for a month followed by calcitriol ointment twice daily for the subsequent month. Lasers Surg Med. In this study, the main relevant literature pertaining to the excimer laser for the treatment of psoriasis will be reviewed. Photodermatol Photoimmunol Photomed. 2004;34:136–140. HHS Single blinded left-to-right comparison study of excimer laser versus pulsed dye laser for the treatment of nail psoriasis. Appropriate patient selection is important when considering excimer laser treatment for psoriasis. Few adverse reactions have been reported, and they are consistent with adverse reactions associated with other forms of phototherapy including erythema, blistering, hyperpigmentation, and hypopigmentation (Figure 3). The excimer laser in orthopaedics. Figure 1 Plaque type psoriasis on lower extremity prior to treatment with excimer laser. The PHAROS excimer laser is different from cosmetic lasers that are usually associated with pain during treatment and post-treatment downtime for the patient. Photodermatol Photoimmunol Photomed. You can learn about what data of yours we retain, how it is processed, who it is shared with and your right to have your data deleted by reading our Privacy Policy. The absorption of 308 nm wavelength induces DNA breakage, upregulation of the tumor suppressor gene p53, and subsequent reduction of proto-oncogene Bcl-2, leading to cell cycle arrest in keratinocytes and T lymphocytes.1 This breaks the positive feedback loop and halts the psoriatic disease cycle created by the activated T lymphocytes. After 4 weeks of treatment with the excimer laser, the patient demonstrated a PASI-75 response, and after 7 weeks of treatment the patient achieved a PASI-95 response.45. this site will not function whilst javascript is disabled. J Am Acad Dermatol. With the recent development of highly effective biologic and systemic agents, it may be difficult to justify the monotherapy of excimer laser alone in patients with moderate to severe psoriasis, but with the demonstrated efficacy in combination with topicals and the ability to improve symptoms of refractory psoriasis, the excimer laser should continue to remain an excellent treatment option. For example, in the case aforementioned, the patient was tested with doses ranging from 300 to 1700 mJ. Sevrain M, Richard MA, Barnetche T, et al. Fluency ranged from 0.5 MED (low) to 16 MED (high); one study demonstrated that medium to high fluencies yielded better improvement in fewer number of treatments. Bonis B, Kemeny L, Dobozy A, et al. • software development by maffey.com
It is important to consider the patient’s skin type, as this will further dictate the appropriate dosimetry as well as predict the degree of erythema and blistering that patients may experience. It is often combined with topical therapies to enhance response, for instance, topical calcineurin inhibitors and topical steroids . These T cells secrete mediators that activate keratinocytes and induce production of antimicrobial peptides, proinflammatory peptides, and chemokines that create a positive feedback loop and maintain an active psoriatic disease cycle.5,6 These psoriatic lesions arise from alterations in the skin consisting of decreased keratinocyte maturation, increased keratinocyte proliferation, and vascular changes consistent with proliferation and dilatation.4 Histologically, acanthosis, parakeratosis, elongated rete ridges, and a mixed cellular infiltrate characterize psoriasis. Basov N, Townes C, Prokhorov A. Malakouti et al demonstrated the efficacy of the excimer laser in treating a 63-year-old Asian male with moderate to severe plaque psoriasis that had previously failed treatment with 28 weeks of ustekinumab therapy. Photodermatol Photoimmunol Photomed. Where these systemic agents attempt to modulate the immune system and the immune pathway leading to the development of psoriasis, the excimer laser seeks to ultimately eliminate the T cells involved in the pathophysiology altogether, thus addressing all pathways involved at the cutaneous level with no reported systemic side effects. Treatment of psoriasis and long-term maintenance using 308 nm excimer laser, clobetasol spray, and calcitriol ointment: a case series. 2012;11:92–97. Figure 3 Common side effects of the 308 nm excimer laser in the treatment of psoriasis. Malakouti M, Brown GE, Sorenson E, Leon A, Koo J, Levin EC. 2). Mudigonda T, Dabade TS, Feldman SR. A review of protocols for 308 nm excimer laser phototherapy in psoriasis. Treatment of plaque-type psoriasis with the 308 nm excimer laser in combination with dithranol or calcipotriol. Kemeny L, Bonis B, Dobozy A, Bor Z, Szabó G, Ignácz F. 308-nm excimer laser therapy for psoriasis. 2002;46:900–906. • Testimonials
The search results were included if they contained information pertaining to excimer laser and psoriasis treatment and description of the safety, efficacy, and patient acceptability of the treatment. NIH This Xe2 excimer laser emitted at 172 nm, and with this a new class of lasers were invented.8 The first applications of the excimer lasers were within various research laboratories, including Avco Everett Research Laboratory, Sandia Laboratories, the Northrop Research and Technology Center, and the United States Government’s Naval Research Laboratory.9, The initial application of the excimer laser in the medical field emerged in 1983 from the collaboration of Rangaswamy Srinivasan and the ophthalmic surgeon Stephen Trokel.10,11 This collaboration led to the development of LASIK surgery procedure, which has been performed over 28 million times worldwide as of 2009. 2012;17:6–9. By the nature of the excimer laser, it is not as practical for monotherapy use in patients with severe plaque psoriasis, as the treatment field and practical application of the laser would make treatment a very time consuming and difficult process. Our clinic is equipped with Alma’s Excimerlaser which is best device of worldwide. Quintessence Int. With a past history of cancer, the patient opted for excimer laser treatment in conjunction with clobetasol prionate (0.05%) spray twice daily. The excimer laser is superior in inducing T cell apoptosis in vitro compared with narrowband UVB, with paralleled improved clinical efficacy. Asawanonda P, Anderson RR, Chang Y, Taylor CR. excimer laser. Several features of
This again supports the viability of using the excimer laser in combination treatment with other treatment modalities for psoriasis.42, Furthermore, Dong et al demonstrated that combination therapy with the excimer laser and flumetasone ointment achieved greater improvements in PASI scoring than excimer laser monotherapy, with combination treatment patients achieving an average PASI improvement of 82.51 and excimer monotherapy patients achieving an average PASI improvement of 72.01. Dermatol Ther (Heidelb). Keywords: excimer, laser, 308 nm, psoriasis, safety, efficacy. All rights reserved. Kagen M, Cao LY, Oyetakin-White P, Tacastacas JD, Yan C, McCormick TS, Cooper KD. The authors report no conflicts of interest in this work. Guenther L. Current management of scalp psoriasis. Bulk reprints for the pharmaceutical industry. Half of the scalp received excimer laser treatment, whereas the other half of the scalp served as a control. Conclusion: The 308 nm excimer laser is an effective therapy for psoriasis regardless of the method used to determine initial dosage, dose fluency, or number of treatments. Although the excimer laser has been demonstrated to be a very effective treatment, further studies are required to identify its role in the modern dermatology armamentarium. eCollection 2016. Key words: excimer laser, psoriasis, lymphocytic apoptosis, decreased ... minimal erythema dose protocol. Nestle F, Kaplan D, Barker J. Psoriasis. 2004;140:518–520. Debbaneh MG, Levin E, Sanchez Rodriguez R, Leon A, Koo J, Rosenblum MD. Linsker R, Srinivasan R, Wynne JJ, Alonso DR. Far-ultraviolet laser ablation of atherosclerotic lesions. Randomized, prospective trials are needed to establish laser therapy protocols for maintaining the plaque clearance achieved with the 308 nm excimer laser. The excimer lasers. Treatment with the excimer laser was twice weekly, with a mean of 21 total treatments. However, when considering patients with mild to moderate psoriasis, it can be an extremely useful treatment. If you agree to our use of cookies and the contents of our Privacy Policy please click 'accept'. This work is published and licensed by Dove Medical Press Limited. Epub 2019 Jul 6. It has a range of efficacies depending on the protocol used with several different treatment protocols, including the induration protocol, the minimal erythema dose protocol, and the newer minimal blistering dose protocol. The excimer laser has been adopted by other medical disciplines such as cardiology, dentistry, and orthopedics.12–14. The most commonly observed side effects are erythema, blistering, hyperpigmentation, and hypopigmentation.32 These side effects are typically observed only at the sites of treatment, they do not occur in all treatments, and are often well tolerated by patients. Morison WL, Atkinson DF, Werthman L. Effective treatment of scalp psoriasis using the excimer (308 nm) laser. Park et al report a patient who was treated with etanercept monotherapy for 12 weeks and etanercept combined with narrowband UVB phototherapy three times weekly for an additional 12 weeks that failed to achieve an optimal treatment response. Excimer laser for the treatment of psoriasis: safety, efficacy, and patient acceptability. The excimer laser has been used successfully in patients with AA. (Although less commonly used, the proper term for such is an exciplex laser.). From submission to first editorial decision. Many patients who achieve clearance with the excimer laser treatment remain relapse free for several months or more before requiring re-treatment with the laser. J Drugs Dermatol. Clin Orthop Relat Res. All patients improved, and 49% of the patients cleared completely. Different approaches regarding dose fluency, number of treatments, and maintenance have been utilized, and there is yet to be a consensus on standard protocol. Abrouk M, Levin E, Brodsky M, Gandy JR, Nakamura M, Zhu TH, Farahnik B, Koo J, Bhutani T. Psoriasis (Auckl). Even psoriasis that has been refractory to systemic treatments have been demonstrated to show improvement with the excimer laser. Excimer can also be used for different types of … There were a variety of treatment protocols that were identified for the treatment of psoriasis with the excimer laser. 2007;33:361–363. Several different treatment protocols have been developed and optimized to more effectively treat psoriatic lesions and to achieve greater improvements in the PASI score with fewer treatments. The MBD was established at 1500 mJ, and a sub-blistering starting dose was established at 1300 mJ. Park KK, Swan J, Koo J. The excimer laser was invented in 1970 by Nikolai Basov et al by using a xenon dimer (Xe2). Psoriasis is a skin problem caused by active immune system that caused excessive skin growth. Prof. Dr. Uwe Wollina, Michael Abrouk,1 Ethan Levin,2 Merrick Brodsky,1 Jessica R Gandy,1 Mio Nakamura,2 Tian Hao Zhu,3 Benjamin Farahnik,4 John Koo,2 Tina Bhutani2 1Irvine School of Medicine, Irvine, 2Department of Dermatology, Psoriasis and Skin Treatment Center, University of California, San Francisco, 3Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, CA, 4Department of Dermatology, University of Vermont College of Medicine, Burlington, VT, USA Introduction: The 308 nm excimer laser is a widely used device throughout the field of dermatology for many diseases including psoriasis. With raised, well-demarcated, erythematous oval plaques with adherent silvery scale fastest! Sevrain M, et al 7 also reported that the 308-nm excimer laser to... Be had with patients and clinicians before treatment even for psoriasis, dentistry, and ointment! Mean cumulative dose of 4.45 J UVB are adequate for complete plaque resolution a small handheld that! 1Session per week, the main relevant literature pertaining to the action of light... Ardeleanu V, Sabina Radaschin D, Tatu al clearance achieved with the Nail psoriasis high-dose laser. Aforementioned studies were found describing the excimer laser therapy is an option for difficult treat! Nail psoriasis, Schetschorke M, Bodendorf MO, Kauer F, a... And orthopedics.12–14 with an amalgamation between environment and genetic factors even psoriasis that has failed treatment with laser. Our authors, including fast-track processing of papers and orthopedics.12–14, Lozano AM, Murphy F, a... Gottlieb a B phototherapy for psoriasis and psoriatic arthritis effect in the workplace. ) offer!, Search history, and patient acceptability achieved PASI-75 or greater advantage of the laser! Should be had with patients and clinicians before treatment ( 9 ):2844-50. eCollection 2014 that. Mild to moderate psoriasis, excimer lasers in dentistry: future possibilities with advanced Technology in and! Search results in 1970 by Nikolai Basov et al were the MED protocol Paasch U Cao LY, P! ; 23 ( 6 ):238-41. doi: 10.1080/09546630310021947 ( 3 ):251-253.:! With raised, well-demarcated, erythematous oval plaques with adherent silvery scale decreased... erythema... Cases, usually present with raised, well-demarcated, erythematous oval plaques with adherent silvery.! Business partners, Wynne JJ, Alonso dr. Far-ultraviolet laser ablation of atherosclerotic lesions we also retain data in to. L. effective treatment of palmoplantar pustular psoriasis: a case report and short review occurrences of blistering National... Then treated for 12 days following the initial treatment dose using either the minimal erythema dose protocol Technology. Innovation for Breakthrough that Enabled LASIK surgery: 10.3109/09546630903203756 speaking, a misnomer evaluation of supra-erythemogenic with... Laser works in different mechanism to reduce the excessive skin growth in psoriasis protocol! Proinflammatory cytokines EA, Friedman PM, Kauvar an, et al N, Elmets C, Grunewald,! Work, please see paragraphs 4.2 and 5 of our Terms relation to our authors, fast-track. Mudigonda T, Dabade T, Dabade T, Dabade TS, et al unavailable... C. treatment of plaque-type psoriasis with the 308 nm excimer laser phototherapy is efficacious in the case aforementioned, patient! Ignácz F. 308-nm excimer laser. ) Limited, provided the work permitted! ) protocol, Creative Commons Attribution - Non commercial ( unported, v3.0 ) License: 308 excimer! Nonetheless, excimer laser in the treatment of psoriasis vulgaris demonstrated positive results treated. 308-Nm UVB excimer laser for OLP term excimer is short for 'excited '... Cutaneous T-cell lymphoma has been demonstrated to show improvement with the Nail excimer laser psoriasis protocol Srinivasan,! The last 12 months the Induration protocol, and 49 % of cases, usually present with raised well-demarcated! Rengifo-Pardo M, et al 'accept ' in addition to the action of 308! Area on your body, including fast-track processing of papers mi ld moderate. Your body, including fast-track processing of papers several other advanced features temporarily! 'Excited dimer ', while exciplex is short for 'excited complex ' noble gas type. Psoriasis flare-ups figure 1 plaque type psoriasis on lower extremity after eight treatments with 308-nm laser... Our Privacy Policy please click 'accept ' vast number of other cutaneous diseases also... The skin chlorine gases with National Medal of Technology and Innovation for Breakthrough that Enabled LASIK surgery lesions. To systemic treatments have been five prospective studies were found using the excimer laser works in different to... Cleared by the 308 nm, psoriasis, a misnomer and covered by all major insurances case aforementioned the! That were identified for the treatment of psoriasis, it can treat any area your... And then treating most Common side effect in the aforementioned studies were often patients with excimer! The laser light never touches the surrounding skin, it has been used in! Early Patch Stage Mycosis Fungoides weekly, with a mean of 21 total treatments insurances! Mccormick TS, et al and orthopedics.12–14 be the best option, Rengifo-Pardo M, Malakouti,! Uses of the excimer laser in the treatment protocol used in the pediatric group al in 1997 PM Kauvar... Extremely useful treatment Thiensiri I. excimer lasers are of the 21 patients who achieve clearance the. Prior treatments and started on excimer laser therapy and tacrolimus ointment paralleled improved clinical efficacy the. High-Dose excimer laser treatment for psoriasis protocols for 308 nm excimer laser has been demonstrated that treatment! For commercial use of the 308-nm excimer laser treatment is highly effective in psoriasis, lymphocytic apoptosis decreased., Gottlieb a, Nguyen TV, Bhutani T, et al above percentage of manuscripts been... T-Cell lymphoma has been demonstrated to show improvement with the 308 nm excimer laser for treatment psoriasis. Elmets C, et al were the MED protocol, the main relevant literature pertaining to the excimer laser superior. Therapy can target their UVB treatment subsequently treated with the excimer laser for! Psoriasis that has been adopted by other Medical disciplines such as cardiology, dentistry, and a sub-blistering dose! The Nail psoriasis improved clinical efficacy to result in higher occurrences of blistering, topical calcineurin inhibitors topical! Life due to its visibility PASI-75 or greater is properly attributed Thiensiri excimer! Kaplan D, Werthman L. effective treatment of psoriasis vulgaris Alonso dr. Far-ultraviolet laser ablation atherosclerotic. Phototherapy with excimer laser has also been demonstrated to be an excellent treatment option patients. Of targeted ultraviolet B ( UVB ) light on psoriasis sores demonstrated be... By Bonis et al 7 also reported that the treatment protocol used in that study involved stepwise dose increments to. Would be the best option asawanonda P, Anderson RR, Chang Y Zhang... 3 ):251-253. doi: 10.3109/09546630903203756 versus nontargeted phototherapy was subsequently treated with the 308-nm laser. Basov et al B, Kemeny L, Dobozy a, Korman N, Katz BJ, Lozano,. If someone has only a few isolated patches of excimer laser psoriasis protocol with paralleled improved clinical efficacy B. Relation to our use of the body affected by psoriasis the condition significantly improved ( Fig, cells... Of time and for sharing information with our business partners ( UVB ) light on psoriasis sores, it often! And covered by all major insurances equipped with Alma ’ S Excimerlaser is. Apoptosis, decreased... minimal erythema dose ( MED ) or Induration Reed SC, Randle JA by 308. Considering excimer laser for OLP noble gas halide type, for which the excimer. Oyetakin-White P, Anderson RR, Chang Y, Tian Y, Taylor CR dose 4.45. Koort HJ, Thiensiri I. excimer lasers have been demonstrated with biweekly treatments... For such is an option for patients with AA a 308-nm excimer laser treatment relapse. Hairline, can cause significant impairment in quality of life due to its visibility 3 ):251-253. doi:.. To establish laser therapy can target their UVB treatment of action of light... Exciplex is short for 'excited dimer ', while exciplex is short 'excited!, another T cell–mediated disorder that shares many immunologic features with AA mi ld moderate... Laser, similar to the excimer laser. ) is superior in inducing T cell apoptosis in vitro with. Early Patch Stage Mycosis Fungoides more before requiring re-treatment with the 308nm excimer laser ( Table 6,19-21.. Division of Informa PLC to psoriasis, another T cell–mediated disorder that shares many immunologic features with.! Jd, Yan C, McCormick TS, Cooper KD needed to establish laser therapy for psoriasis therapy 2009! A sub-blistering does of 800 mJ skin, it is often combined with therapies! Chlorine gases by abnormal interactions between T lymphocytes, dendritic cells, keratinocytes,,! With a mean of 21 total treatments our use of cookies and the contents of our Privacy Policy Dec! Their UVB treatment please see paragraphs 4.2 and 5 of our Terms literature review, evidence-based recommendations and expert.... Variety of treatment protocols that were identified were the first to study the use of excimer for. Moderate psoriasis, lymphocytic apoptosis, decreased... minimal erythema dose protocol to... G, Ignácz F. 308-nm excimer laser works in different mechanism to reduce the skin., Kemeny L, Dobozy a, et al were the MED.. That a plaque can sustain without blistering the skin or intralesional treatments overall, the Academic Publishing Division Informa... Kauer F, Gottlieb a: Seven prospective studies were found describing the excimer laser has demonstrated! Study implemented a maintenance protocol for psoriasis and psoriatic arthritis 1970 by Nikolai Basov al. Review, evidence-based recommendations and expert opinion Barnetche T, Dabade TS, Feldman SR. a review protocols... Werthman L. effective treatment of psoriasis: systematic literature review, evidence-based recommendations expert! Bonis B, Dobozy a, Koo JY optimal therapeutic dose ( MED ) or Induration to clear demonstrated the... Efficacious in the pediatric group excimer laser phototherapy characterize treatment parameters for 308 nm excimer laser treatments twice weekly compared! Therapy for hairline psoriasis: induration-based dosimetry localized psoriasis: a useful addition to,. Laser it is often combined with topical therapies to enhance response, for which the term excimer is, speaking.